Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes.
نویسندگان
چکیده
Boiled coffee contains an unidentified lipid that raises serum cholesterol. We studied the effects of the ingestion of coffee oil fractions of increasing purity in volunteers in order to identify the cholesterol-raising factor. In 15 volunteers who ingested 0.75 g/d of a non-triglyceride-fraction from coffee oil for 4 weeks, mean cholesterol increased by 48 mg/dl (1.2 mmol/l) relative to placebo. In contrast, a coffee oil stripped of the non-triglyceride lipids cafestol and kahweol had no effect. In three volunteers, purified cafestol (73 mg/d) plus kahweol (58 mg/d) increased cholesterol by 66 mg/dl (1.7 mmol/l) after 6 weeks. Oil from Robusta beans, which contains cafestol but negligible kahweol, also raised serum cholesterol. These findings show that cafestol is at least partly responsible for the cholesterol-raising effect of boiled coffee. Coffee oils and brews containing cafestol consistently increased serum triglycerides and alanine amino-transferase, and depressed serum creatinine and gamma-glutamyl-transferase (GGT). After withdrawal GGT activity rose above baseline. Norwegians who habitually consumed 5-9 cups of boiled coffee per day had higher serum cholesterol levels and lower GGT but no higher alanine aminotransferase activity than controls. Thus, serum cholesterol is raised by cafestol and possibly also kahweol, both natural components of coffee beans. The mechanism of action is unknown but is accompanied by alterations in liver function enzymes.
منابع مشابه
The Comparison of Pretreatment Effects of Boiled Coffee and Curcuruma Longa on Serum Albumin as a Liver Indicator in Male Rats Injected with Tioacetamide
Background & Objective: Due to the vital role of liver in the detoxification, the present study determined the pretreatment effects of boiled coffee and Curcuruma Longa on serum Albumin as a liver indicator in male rats treated with tioacetamide. Materials & Methods: In this study, 56 male rats were divided into 7 groups of 8. During their pretreatment period of 68 days, the boiled coffee, ...
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عنوان ژورنال:
- Journal of lipid research
دوره 35 شماره
صفحات -
تاریخ انتشار 1994